CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins.

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CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction. CD47 and SIRPA are co-expressed in some cell types, and signaling functions involving lateral interactions have been proposed but not clearly established (Maile et al., 2003). CD47-induced SIRPA signaling in macrophages plays a role in limiting phagocytosis of RBCs, stem cells, and tumor cells. CD47 - Explore an overview of CD47, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. ever, CD47 is found to be overexpressed on cancer cells. CD47–SIRPα interaction inhibits macrophage phagocytosis, allowing cancer cells to escape immune surveillance.

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Furthermore, it plays a key role in immune and  CD47 Antibody (MAIP301) is a monoclonal anti-CD47 antibody that detects mouse and rat CD47 by WB, IP, IF and FCM. Cited in 19 publications. 10 Nov 2020 CD Markers - CD47. Interaction of CD47 with SIRPα on macrophages and dendritic cells can downregulate immune cell activity by activating  Stains human CD47 transfectants but not irrelevant transfectants. Source. Monoclonal Mouse IgG1 Clone # 472603. Purification.

Macrophages as components of the innate immune system play a critical role in antitumor responses. Strategies for targeting CD47 are becoming a hot spot for cancer therapy.

Table of contents. Förord 9; Inledning 11; Gapinstinkten 31; Försämringsinstinkten 63; Linjärinstinkten 95; Rädsloinstinkten 125; Storleksinstinkten 151 

“There may be circumstances where host responses need boosting and CD47 represents a novel target for host-directed therapies in such cases,” the scientists write, mentioning SARS-CoV-2, HIV, HPV and Ebola virus among several possibilities. Article. M Caspi Tal et al.

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It also activates CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha . CD47 is a transmembrane glycoprotein, widely expressed in the large majority of human tissues, where it functions as a ligand for several receptors, including thrombospondin and signal regulatory protein alpha (SIRPα). From: Blood Cells, Molecules, and Diseases, 2015. Download as PDF. About this page. CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis.

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CD47 is cell surface protein that regulates the innate immune system by serving as an inhibitory signal for phagocytosis by macrophages, dendritic  1 Nov 2018 Abstract Background The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces  26 May 2017 In blood cancer, tumor cells expressing CD47 evade phagocytosis by macrophages, leading to a poor patient prognosis. However, the status of  CD47 is a cell surface glycoprotein and is expressed on all normal cells in the body.

The B6H12 monoclonal antibody reacts with human CD47 otherwise known as integrin-associated protein (IAP), and neurophilin. CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. cd47_human

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cd47_human

This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries.

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CD47 CD47 molecule. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).

M Caspi Tal et al. Upregulation of CD47 is a host checkpoint response to pathogen recognition. CD47 is a ubiquitously immune-regulatory protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells by binding to phagocyte-expressed signal regulatory protein alpha (SIRPα). CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response. “There may be circumstances where host responses need boosting and CD47 represents a novel target for host-directed therapies in such cases,” the scientists write, mentioning SARS-CoV-2, HIV, HPV and Ebola virus among several possibilities.

Free. LIBRIS titelinformation: Role of the CD47/SIRPα-interaction in regulation of macrophage phagocytosis / Mattias Olsson. Gilead Sciences Inc. Gilead's Magrolimab, an Investigational Anti-CD47 Monoclonal Antibody, Receives FDA Breakthrough Therapy Designation  Study of SHR2150 (TLR7 Agonist) in Combination With Chemotherapy Plus PD-1 or CD47 Antibody in Subjects With Unresectable/ Metastatic Solid Tumors.